منابع مشابه
Trials and tribulations in lupus anticoagulant testing.
This issue of Clinical Chemistry and Laboratory Medicine includes a report by Pradella and colleagues regarding a cooperative multicentre study to define the upper limits of normal for several tests used in the diagnostic assessment of lupus anticoagulant (LA) [1] . In total, 200 normal samples were assessed, comprising 40 from each of five centres, for a total of six functional LA assays. Each...
متن کاملDevelopment of consensus guidelines for anticardiolipin and lupus anticoagulant testing.
Interlaboratory and intermethod variation in commercial and in-house tests used for the measurement of anticardiolipin antibodies (aCL) and lupus anticoagulant (LA) limit the diagnostic value of the results from these tests. This short review summarizes published and unpublished guidelines (some developed using consensus procedures) on aCL and LA testing that are aimed at decreasing assay varia...
متن کاملEpilepsy associated with lupus anticoagulant
INTRODUCTION Lupus anticoagulant (LA) is commonly present in patients with systemic lupus erythematosus (SLE) who present with an ischemic cerebral stroke. Reports have noted the presence of LA in patients with epilepsy who do not have SLE. These patients are usually elderly, and it has been postulated that their epilepsy is due to subclinical ischemic infarcts. METHODS Two cases are presente...
متن کاملIncreased mortality in patients with the lupus anticoagulant: the Vienna Lupus Anticoagulant and Thrombosis Study (LATS).
Data on the clinical course of lupus anticoagulant (LA)-positive individuals with or without thrombotic manifestations or pregnancy complications are limited. To investigate mortality rates and factors that might influence mortality, we conducted a prospective observational study of LA-positive individuals. In total, 151 patients (82% female) were followed for a median of 8.2 years; 30 of the p...
متن کاملLupus anticoagulant, anticardiolipin antibodies, fetal loss, and systemic lupus erythematosus.
UPUS ANTICOAGULANTS (LA) and anticardioL lipin (ACL) antibodies (ACLA) belong to a heterogenous group of antibodies directed against negatively charged pho~pholipids.l-~ However, more recent studies would suggest that these antibodies are directed to epitopes of other proteins that are complexed with negatively charged phospholipid~>-~ Although antiphospholipid antibodies are frequently found i...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2010
ISSN: 0002-9173,1943-7722
DOI: 10.1309/ajcp4spplg5xvixf